Why can PCSK9 lower cholesterol?
36 years old
2018-05-01
Last time I saw the news, I said that scientists have found the latest type of lipid-lowering drug-PCSK9 inhibitor. It can reduce blood cholesterol levels by 60%, so why can PCSK9 lower cholesterol?
1 Answer These messages are for reference only
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BY Ina Barton 2018-05-01The PCSK9 gene plays a "braking" role in the synthesis of LDLR, that is, the normal PCSK9 gene functions to prevent too much LDLR on the surface of liver cells. After the mutation of this gene, the brake fails, resulting in excessive LDLR on the surface of liver cells. Blessed by disaster, let these people get The "super power" to break down/clear blood cholesterol.5
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